Seventh Wave operates in an FDA-inspected, AAALAC-accredited facility with an AALAS-certified staff to offer various models, study designs, and custom endpoints that provide value to your research efforts. In Vivo studies may be conducted in several species and with a variety of administration routes.
 
 Approved species list: 

  • Rats
  • Mice
  • Canines
  • Hamsters
  • Guinea pigs
  • Rabbits
  • Cynomolgus monkeys
  • Miniature swine

 Approved administration routes: 

  • Intravenous (bolus and infusion)
  • Oral (gavage, capsule, and dietary)
  • Intramuscular
  • Subcutaneous
  • Intraperitoneal
  • Intranasal
  • Intratracheal
  • Dermal
  • Ocular (topical and intracameral)  
  • Intra-articular
  • Mini-pump infusion
  • Culex continuous infusion and blood sampling

 
Clients may select from a standard study design to assess commonly investigated endpoints or, customize their study design to examine parameters of unique interest. Seventh Wave emphasizes studies in the following areas: 
 
Pharmacokinetic (PK)/Pharmacodynamic (PD)

  • Comparative PK (intravenous vs. a second route of administration)
  • Cassette dosing varying from two to ten compounds
  • Crossover designs 

Toxicological/ Toxicokinetic (TK)

  • Acute tolerability
  • Ascending/descending dose range-finding
  • Repeated dose exploratory studies to identify maximum tolerated doses and target organ toxicity
  • Investigative studies to understand adverse pharmacology or toxicology 

Pharmacological and Transgenic Models of Disease 

  • Cardiovascular
  • Hepatic
  • Oncology
  • Metabolic/Diabetes
  • Respiratory
  • Inflammation
  • Intraocular Pressure (IOP)

Endpoints are customizable to the client's expectations, but typically include: 

  • Clinical observations
  • Clinical pathology (hematology, clinical chemistry, coagulation, urinalysis)
  • Gross necropsy
  • Histopathology by board-certified pathologists
  • Bioanalysis of plasma, urine and tissue samples 

Additional endpoints available: 

  • Ophthalmic exams
  • ECG evaluation in non-rodents

Integration of our In Vivo services with our bioanalytical, PK/PD/TK, toxicology, and pathology capabilities allows for rapid, yet customized, progression of your exploratory research and development.