Publications
Lickteig AJ, Riley R, Melton RJ, Reitz BA, Fischer HD, and Stevens JC (Submitted 2009) Expression and Characterization of Functional Dog Flavin-Containing Monooxygenase 3. Drug Metabolism and Disposition.
Hutzler JM, Melton RJ, Rumsey JM, Thompson DC, Rock DA, Wienkers LC (2008) Assessment of the Metabolism and Intrinsic Reactivity of a Novel Catechol Metabolite. Chem Res. Toxicol. 21, 1125-1133
Hutzler JM, Melton RJ, Rumsey JM, Schnute ME, Locuson CW and Wienkers LC (2006) Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions. Chem Res. Toxicol. 19, 1650-1659.
Stevens JC, Melton RJ, Zaya MJ, Engel LC. (2003) Expression and Characterization of Functional Dog FMO I. Mol Pharm 63:271-275.
Blanco G, Sanchez G, Melton RJ, Tourtellotte WG, Mercer RW. (2000). The a4 Isoform of the Na,K-ATPase is Expressed in the Germ Cells of the Testes. Journal of Histochemistry and Cytochemistry.
Blanco G, Melton RJ, Sanchez G, Mercer RW. (1999). Functional Characterization of a Testes-Specific a-Subunit Isoform of the Sodium / Potassium Adenosinetriphosphatase. Biochemistry.
Blanco G, Melton RJ, Sanchez G, Mercer RW. (1999). a4, A Functional a Isoform of the Na, K-ATPase of Testes. Annals NY Acad. Sci.
March TH, Barr EB, Finch GL, Nikula KJ, and Seagrave JC: Effects of Concurrent Ozone Exposure on the Pathogenesis of Cigarette Smoke-Induced Emphysema in B6C3F1 Mice. Inhalation Toxicology, 14(12):1187-213, 2002.
Heyen J, Blasi E, Rudolph A, Frierdich G, VanVleet J, and Nikula KJ: Structural, Functional, and Molecular Characterization of the SHHF Model of Heart Failure. American Journal of Physiology - Heart and Circulatory Physiology, 283: H1775-H1784, 2002.
Nikula KJ, Vallyathan V, Green FHY, and Hahn FF. Influence of Exposure Concentration or Dose on the Distribution of Retained Particulate Material in Rat and Human Lungs. Environmental Health Perspectives, 109: 311-318, 2001.
Nikula KJ and Green FHY: Animal Models of Chronic Bronchitis and Their Relevance to Studies of Particle-Induced Disease. Inhal. Toxicol. 12: 123-153, 2000.
Nikula KJ: Rat Lung Tumors Induced by Exposure to Selected Poorly Soluble Nonfibrous Particles. Inhal. Toxicol. 12: 97-119, 2000.
March TH, Green FHY, Hahn FF, and Nikula KJ: Animal Models of Emphysema and Their Relevance to Studies of Particle-Induced Disease. Inhal. Toxicol.12: 155-187, 2000.
Conn CA, Green FHY, and Nikula KJ: Animal Models of Pulmonary Infection in the Compromised Host: Potential Usefulness for Studying Health Effect of Inhaled Particles. Inhal. Toxicol. 12:783-827, 2000.
March TH, Kolar LM, Barr EB, Finch GL, Ménache MG, and Nikula KJ: Enhanced Pulmonary Epithelial Replication and Axial Airway Mucosubstance Changes in F344 Rats Exposed Short-Term to Mainstream Cigarette Smoke. Toxicol. Appl. Pharmacol. 161:171-179, 1999.
Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, and Herman JG: Aberrant Methylation of p16INK4a is an Early Event in Lung Cancer and a Potential Biomarker for Early Diagnosis. Proc. Natl. Acad. Sci. USA 95: 11891-11896, 1998.
Nikula KJ, Avila KJ, Griffith WC, and Mauderly JL: Lung Tissue Responses and Sites of Particle Retention Differ Between Rats and Cynomolgus Monkeys Exposed Chronically to Diesel Exhaust and Coal Dust. Fundam. Appl. Toxicol. 37: 37-53, 1997.
Spencer JF, Sagartz JE, Wold WSM, and Toth K. New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster. Cancer Gene Therapy (doi:10,1038/cgt.2009.36), 2009.
Schultz DA, Huso D, Sagartz JE, and Buller RML. Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus. Virology (doi:10.1016/j.virol.2008.09.025), 2008.
SChaecher SR, Stabenow J, Oberle ., Schriewer J, Buller RM, Sagartz JE, and Pekosz A. An immunosuppressed Syrian golden hamster model for SARS-CoV infection. Virology, 380:312-321 (doi:10.1016/j.virol.2008.07.026), 2008.
Toth K, Spencer JF, Dhar D, Sagartz JE, Buller RM, Painter GR, and Wold WS. Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model. Proceedings of the National Academy of Sciences USA, 105(20): 7293-7297, 2008.
Kramer JA, Sagartz JE, and Morris DL. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery, 6:636-649 10.1038/nrd2378), 2007.
Tugendreich S, Pearson CI, Sagartz JE, Jarnagin K, and Kolaja K. NSAID-induced acute phase response is due to increased intestinal permeability and characterized by early and consistent alterations in hepatic gene expression. Toxicologic Pathology, 34:168-179, 2006.
Storer RD, French JE, Haseman J, Hajian G, LeGrand EK, Long GG, Mixson LA, Ochoa R, Sagartz JE, and Soper KA. P53+/- hemizygous knockout mouse: Overview of available data. Toxicologic Pathology, 29:30-50, 2001.
McClain RM, Keller D, Casciano D, Fu P, MacDonald J, Popp J, and Sagartz JE. Neonatal mouse model: Review of methods and results. Toxicologic Pathology, 29:128-137, 2001.
Alden CA, Sagartz JE, Smith PF, Wilson AG, Bunch RT, and Morris DM. The pathologist and toxicologist in pharmaceutical product discovery. Toxicologic Pathology, 29:128-137, 2001.
Sagartz JE, Curtiss SW, Bunch RT, Davila JC, Morris DL, and Alden CA> Phenobarbital does not promote hepatic tumorigenesis in a 26-week bioassay in p53 heterozygous mice. Toxicologic Pathology, 29:492-500, 1998.
ABSTRACTS/PRESENTATIONS
Connor R, Sloan J, Shen J, Freeman M, Sugarman B, Ludington E, Nicol F, Roth D, Frost G, Vick A, Vaugh D. 2009. Recombinant human hyaluronidase (rHuPH20) accelerates insulin PK n dogs. National Biotechnology Conference.
Alsina J, Bokvist K, Zhang L, Cummins R, Vick A, Brenner M, Mayer J. 2009. Selective VPAC-2 ligands as potential anti-diabetic agents. American Peptide Symposium.
Sloan J, Gidda J, Zhang L, Smiley D, DiMarchi R, Vick A, Bowsher R. 2009. Competitive immunoassay strategy for the rapid establishment of bioanalytical methods to support pharmacokinetic assessments in lead optimization studies for PEGylated peptide therapeutics. American Peptide Symposium.
Snow M, Butler R, Vick A, Sloan J, Bowsher R. 2008. Validation of a capture:elution electrochemilumenescence assay to detect anti-drug antibodies with high sensitivity and drug tolerance. Annual meeting of the American Association of Pharmaceutical Scientists.
Smidt M, Hantash J, Vick A, Bowsher R. 2008. The use of a novel antibody selection approach to develop and validate a highly sensitive and selective ELISA assay to detect Cetuximab. Annual meeting of the American Association of Pharmaceutical Scientists.
Freeman M, Tajkowski P, Sloan J, Bowsher R, Kamerud J, Vick A. 2008. A radioimmunoassay for the quantitative determination of 'free concentrations' of immunoreactive insulin glargine in human serum. National Biotechnology Conference.
Yocum R, Sugarman B, Vaugh D, Vick A, Brunelle R, Frost G. 2008. Pharmacokinetics and glucodynamics of an insulin analog injected with recombinant human hyaluronidase: fast-acting insulin analog made faster. Annual meeting of the American Diabetes Association.
Snow M, Smidt M, Hantash J, Vick A. 2008. A comparison between ECL and fluorescence methods for the determination of phosphorothioate antisense oligonucleotides in human plasma using a locked nucleic acid ligation hybridization assay. Tides.
Hantash J, Snow M, Vick A, Bowsher R. 2008. Over coming the challenges in the immunogenicity assessment of biotechnology-derived therapeutic proteins to satisfy regulatory requirements. Society of Quality Assurance.
INVITED LECTURES
Vick A. 2009. Engineering better medicines: new approaches to biotherapeutics. Pharmaceutics Graduate Student Research Meeting. Purdue University.
Vick A. 2009. PEGylation strategies for PK/PD optimization of peptide therapeutics". American Peptide Symposium.
Vick A. 2008. Fit for purpose biomarker validation and qualification. AAPS.
Vick A. 2008. Antisense Discovery and Development. DIA Workshop.
Vick A, Glaesner W. 2008. Alternative Scaffolds: Beyond antibody-based therapeutics. National Biotechnology Conference.
Vick A. 2008. Graduate Student Symposium in Biotechnology. National Biotechnology Conference.
Vick A. 2008. Ligand binding training course: Basic pharmacokinetic principles related to bioproduct discovery and development. National Biotechnology Conference.
Vick A, Glaesner W. 2008. A glimpse into the future of biotechnology. University of Missouri-Columbia Department of Biological Sciences.
PUBLICATIONS
Glaesner W, Vick A, Milican R, Ellis B, Tschang S, Tian Y, Bokvist K, Brenner M, Koester A, Porksen N, Etgen G, Bumol T. 2009. Engineering and characterization of the long-acting GLP-1 analog LY2189365, an Fc fusion protein. Diabetes, Accepted.
Vaughn D, Yocum R, Muchmore D, Sugarman B, Vick A, Bilinsky I, and Frost G. 2009. Accelerated pharmacokinetics and glucodynamics of prandial insulins injected with recombinant human hyaluronidase. Diabetes Technology & Therapeutics, 11(6): 345-352.
Kohn W, Micanovic R, Myers S, Vick A, Kahl S, Zhang L, Strifler B, Li S, Shang J, Beals J, Mayer J, and DiMarchi R. 2007. pl-shiftedInsulin analogs with extended in vivo time-action and favorable receptor selectivity, Peptides, 28(4):935-948.
Vick A, Wolff R, Koester A, Reams R, Deaver D, and Heidel S. 2007. A 6-month inhalation study to characterize the toxicity, pharmacokinetics, and pharmacodynamics of a human inhaled insulin powder (HIIP) in beagle dogs. J Aerosol Med, 20(2):112-126.
Jones K, Owusu-Ababio G, Vick A, and Khan A. 2006. Pharmacokinetics and hepatic extraction of recombinant human parathyroid hormone in rat, dog, and monkey. J Pharm Sci, 95:2499-2506.
Zhang XY, Zhang JW, Chen B, Bai ZT, Shen J, Ji YH. Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch. Brain Res Bull. 2002 May;58(1):27-31.
Vishal S. Narang, Charles Fraga, Narendra Kumar, Jun Shen, Stacy Throm, Clinton F. Stewart, and Christopher M. Waters. Dexamethasone increases expression and activity of multi-drug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol 2008 Aug;295(2):C440-50.
Jun Shen, Charles Fraga, Christopher Calabrese, M Beth McCarville, Paula Schaiquevich, Clinton F. Stewart. A Modified Surgical Procedure for Microdialysis Probe Implantation in the Lateral Ventricle of a FVB Mouse. J Pharm Sci. 2008 Nov;97(11):5013-23.
Jun Shen, Angel Carcaboso, Elaine Hubbard, Henry Wynn, Hohn C. Panetta, Christopher Waters, Mohamed Elmeliegy, Clinton Stewart. Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res. 2009 Jul 15;69(14):5885-92.
Angel Carcaboso, Mohamed Elmeliegy, Jun Shen, Stephen Juel, Ziwei Zhang, Clinton Stewart et al. Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of orthotopic glioma xenografts. Cancer Res. 2010 Jun 1;70(11):4499-508.
Tagen M, Zhuang Y, Zhang F, Harstead KE, Shen J, Schaiquevich P, Fraga CH, Panetta JC, Waters CM, Stewart CF.P-glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice. Drug Metab Lett. 2010 Jun 28.
Ronjon Chakraverty, Guillermo Orti, Michael Roughton, Jun Shen, Adele Fielding, Panos Kottaridis, Donald Milligan et. al. Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantat ion: pharmacokinetics, GVHD and immune reconstitution. Blood. 2010 Jun 29
Recent Abstracts:
Angel M. Carcaboso, Mohamed A. Elmeliegy, Jun Shen, Stephen J. Juel, Ziwei M. Zhang, Christopher Calabrese, Lorraine Tracey, Christopher M. Waters, Clinton F. Stewart. A tyrosine kinase inhibitor enhances topotecan penetration of orthotopic glioma xenografts, 2010 AACR
Jun Shen, Alex Oh, Barry Sugarman, Douglas Muchmore, Ron Bowsher, Daniel Vaughn Transit Model Effectively Parameterizes Insulin Pharmacokinetic Curves Following Subcutaneous Injection, Advanced Technologies and Treatments for Diabetes - ATTD 2010
Robert J. Connor, John H. Sloan, Jun Shen, Megan M. Freeman et. al Recombinant Human Hyaluronidase (Rhuph20) Accelerates Insulin Pharmacokinetics In Dogs, 2009 AAPS National Biotechnology Conference
Angel M. Carcaboso, Jun Shen, Mohamed Elmeliegy, Stephen Juel, Clinton F. Stewart Assessment of topotecan penetration in orthotopic glioma xenografts using intracerebral microdialysis, 2009 AACR